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Identification and clarification of the role of key active site residues in bacterial glutathione S-transferase zeta/maleylpyruvate isomerase
Though short term (48 hours) resistance to MTX seemed to be directly related to cellular proliferation, resistance in longer exposure times (96 hours) was associated with glutathione (GSH) levels
High Hcy levels are often caused by low intake or poor metabolism of vitamins B6, B9, and B12 (found in green vegetables and citrus) or by gene mutations that affect Hcy breakdown
N-acetylcysteine ( NAC) and alpha lipoic acid (ALA) are also used to increase GSH levels
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